Long ago, I posted here the steps involved in setting up R packages for performing constraint based modelling (CBM) of genome scale metabolic models. It was Ubuntu 10.04 LTS back then. Now, I am trying to reproduce the same set-up on Ubuntu 13.10. As a quick summary, we need the following R packages: "sybil", "sybilSBML", and "glpkAPI". The "sybilSBML" R package requires the Bioconductor package "rsbml" which requires "libsbml" library, which in turn depends on "swig". The "glpkAPI" is an R wrapper for glpk library which is the optimization engine. I have been able to install all these packages by executing the following steps. 1. Install swig from ubuntu repositories. sudo apt-get install swig 2. Install python-dev from ubuntu repositories. sudo apt-get install python-dev 3. Install openjdk from ubuntu repositories. sudo apt-get install openjdk-7-jdk 4. Install libxml2 and libxml2-d